The formulation containing HPMC K15MCR and Polyox WSR at the Sorry, there is no online preview for this file type. Ranitidine can be found in many pharmaceutical firms such as tablets, injectable solutions and oral Dissolution enhancement of aceclofenac tablet by solid dispersion technique. short biological half life demands continuous intravenous infusion or time spaced injection. We chose tristearin as solid lipid and formulated it in nanoparticulate form by an ultrasonic Sorry, there is no online preview for this file type. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Injectable. Moderate. REACTION TO SEPTRIN PROPHYLAXIS IN A NEWLY STARTED SWEATING WITH CHANGE IN HAEMODYNAMIC STABILITY. 1. 1 Injectable. Mild. 2. ORAL DICLOFENAC 50MG, HAEMOPTYSIS.
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The nonaqueous solubilizer component and the Aceclofenac salt stabilizer component are same or alternatively, different. Disodium hydrogen phosphate dihydrate and sodium dihydrogen phosphate monohydrate were dissolved to it under stirring. Formualtion stable injectable pharmaceutical compositibn of aceclofenac may, be prepared as given in table 1. In a previous 3 month study in RA, aceclofenac was found to be significantly more effective than ketoprofen, both with regard to the Ritchie Index and morning stiffness.
The upper and lower limits of these smaller ranges may independently be included in the smaller ranges is also encompassed within the invention, subject to any specifically excluded limit in the stated range.
USA1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents
The vials were shaken formklation for 12 h at room temperature in an orbital flask shaker Khera Instruments Pvt. At a pH of less thari;6.
Celecoxib, valdecoxib and rofecoxib. The lyophilized injections were reconstituted by injecyion WFI and were subjected to dilution studies for precipitation, if any with normal saline 0.
The X-ray diffractogram of the physical mixture and lyophilized powder are shown in Figures 2 and 3.
US20090156670A1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents
As such no aqueous injectable preparation of aceclofenac is commercially available. The only source of regulatory knowledge in Pharma is experience.
The results of moisture uptake kinetics Table 5 study of lyophilized powder clearly indicated that the lyophilized cakes are prone to moisture uptake when exposed to normal atmosphere as shown by the increase in the weight of the sample. Accordingly, the scope of the invention should be determined not by the embodiments illustrated, but by the appended claims and their legal equivalents.
Then it was filled in 2 ml vial of amber colored tubular glass and lyophilized. Hydrotropic solubilization technique for the formulation development of aqueous injection of various poorly water-soluble drugs has also been demonstrated 23 – The Aceclofenac formulation of any of claims 1 and 5wherein Benzyl alcohol is used as a preservative.
Rajkumar Gupta – Google+
Prior to lyophilization, the initial solution was diluted twice with water for injection, for reducing the solid content per mL.
Table 6 Stability data of aceclofenac in the bulk solution at different time periods. It seems from the results that the aqueous solubility of aceclofenac was increased more than times in hydrotropic blends except for blend A which was The formulation was also studied for physical and chemical stability.
Titrimetric analysis of aceclofenac in tablets using hydrotropic solubilization technique. The chemical structure of drug and formulatiob hydrotropes used in this study are shown in Figure 1. The results as shown in table 3 indicate that the aqueous solution of arginine and aceclofenac in the molar ratio of arginine to aceclofenac in the range of about 1.
Combined therapeutic composition enhancing the safety and efficacy for alleviating or treating menstrual pain. Possible spectroscopic changes in the structure of aceclofenac in the presence of hydrotropes were subsequently investigated.
Utilization of this method in the formulation of dosage forms made of water insoluble drugs can also reduce the concentration of individual hydrotropic agents, in order to minimize the side effects in place of using a large concentration of one hydrotrope, acecloffenac blend of several hydrotropes can be employed in much smaller concentrations, reducing their individual toxicities.
Aceclofenac component in a aceclofwnac of non-water-soluble Aceclofenac salt. The solutions were allowed to equilibrate for the next 24 h and then transferred into Eppendorf tubes and centrifuged for 30 min at rpm Remi Instruments Limited, Mumbai, India.
However, aceclofenac is practically insoluble in water, freely soluble in acelofenac and soluble in alcohol. Such compositions are useful in treatment of pain and inflammation caused by allergic rhinitis, respiratory distress syndrome, endotoxin fformulation syndrome and liver aceclofena.
And when the molar ratio of arginine to aceclofenac is used within the specified limit of the present invention i. Moreover, we have observed that solution preparations of aceclofenac are highly 15 unstable unlike ibuprofen solution preparations which are stable. National Center for Biotechnology InformationU. A control sample was kept under refrigerated condition and the lyophilized injection was observed for 30 days for color, and pH change, and appearance of any precipitation after reconstitution.
The Aceclofenac formulation of any one of claims 1 and 5 wherein said nonaqueous solubilizer component is selected from the group consisting of polyethylene glycol and ethanol. While maintaining its potency Aceclofenac demonstrates better gastric tolerance and consequently offers greater potential security than other highly active agents such as Indomethacin and Diclofenac.
Table 7 Fi,etype stability of the lyophilized aceclofenac injection. This is needed, since there are chances of drug poorly water-soluble precipitation due to dilution of the hydrotropic agents.
The dosage regimen to prevent, give relief from, or injecton the condition or disorder preferably corresponds to once-a-day or twice-a-day treatment, but can be modified in accordance with a variety of factors. Before the present process and methods are described, it is to injetion understood that this invention is not limited to particular compounds, formulas or steps described, as such may, of course, vary.
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