ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .
| Author: | Zulkigis Vudokazahn |
| Country: | Mongolia |
| Language: | English (Spanish) |
| Genre: | Video |
| Published (Last): | 13 March 2009 |
| Pages: | 292 |
| PDF File Size: | 8.31 Mb |
| ePub File Size: | 18.7 Mb |
| ISBN: | 709-2-19137-417-6 |
| Downloads: | 4590 |
| Price: | Free* [*Free Regsitration Required] |
| Uploader: | Tagami |
The plant is reported to show abortifacient [ 7 ], antimicrobial [ 89 ], and antitussive activities qdhatoda 10 ]. Materials and Methods 2. Vasicine acetate exhibited good zone of inhibition against bacteria: Sample ethanol extract Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals.
Antibacterial activity of adhatoda vasica leaf extract
B revised New Delhi, India: Kulkarni [ 24 ] reported that A. Vasicine is reported to have bronchodilatory, respiratory stimulant, and uterine stimulant effects [ 14 ]. Accumulation of vasicine and vasicinone in tissue cultures of Adhatoda vasica and evaluation of the free radical-scavenging activities of the various crude extracts.
Essential oils of the leaves of A. Vasicine hydrochloride, a new drug for interruption of pregnancy. Zones of inhibition were recorded in millimetres and the experiment was repeated twice. Potent uterine activity of alkaloid vasicine. Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi. Instruments All melting point values are uncorrected and taken by open capillary method on a heating block Instrument. National Center for Biotechnology InformationU.
The emergence of drug-resistant pathogens and the increase in diseases affecting the immune system have greatly intensified the need to investigate new bioactive metabolites for potential pharmaceutical and industrial applications [ 12 ]. Journal List Biomed Res Int v.
Every year, at leastpeople die activiy from cancer related to their workplace [ 3 ]. Indian Journal of Microbiology.
The MIC for bacteria was determined as the lowest concentration of the compound inhibiting the visual growth of the test cultures on the agar plate.
International Journal of Cancer.
BoxRiyadhSaudi Arabia. Al-Dhabi1 C. Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ]. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. The column was eluted with chloroform and chloroform: The antifungal agent Ketoconazole for fungi and antibacterial agent Streptomycin for bacteria were included in the assays as positive controls.
Further elution of the column with chloroform: Two mobile phases A and B were used at flow rate antimocrobial 1. The plant was identified by Dr. The plant contains alkaloids such as Vasicine, vasicinone, deoxyvasicine, vasicol, adhatodinine, and vasicinol [ 12 ]. Minimum Inhibitory Concentration MIC Minimum adhatida concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ].
It was studied for antimicrobial, antioxidant, and anticancer activities. Sankar2 and K. Ignacimuthu and Shanmugam [ 15 ] have reported the antitubercular activity of Vasicine acetate isolated from A. Shade dried and coarsely powdered leaves of A.
Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper
The free radical scavenging activity was calculated as follows:. The estimation of Vasicine acetate content in the extract was performed using linear regression analysis. Negative control was prepared using respective solvents. Cytotoxicity of each sample was expressed as IC 50 value. Author information Article notes Copyright and License information Disclaimer. Journal of Natural Products.
In the present communication we report the antimicrobial, antioxidant, and anticancer effects of Vasicine acetate acetylated from Vasicine obtained from A.
Published online Jan The compound showed prominent cytotoxic activity in vitro against A lung adenocarcinoma cancer cell line. Vasicine acetate was obtained by acetylation of Vasicine. Other constituents include vitamin C, saponins, flavonoids as well as steroids, and fatty acids [ 13 ]. Open in a separate window. Asian Pacific Journal of Tropical Biomedicine. Clinical and Laboratory Standards Institute; Investigation on antifeedant and anthelmentic potential of Adhatoda vasica nees.
Antimicrobial and antimycobacterial activities of methyl caffeate isolated from Solanum torvum Swartz.
Estimates of worldwide burden of cancer in Indian Journal of Natural Products and Resources.