Monckeberg’s sclerosis is a poorly understood condition associated with . Monckeberg’s sclerosis can coexist with atherosclerotic disease. Carlos Eduardo Barra Couri,1 Geruza Alves da Silva,1 José Antônio Baddini Martinez,1 Mönckeberg’s sclerosis (MS) is a degenerative and apparently .. The current concepts of the pathogenesis of Monckeberg-type arteriosclerosis. Mönckeberg sclerosis (MS) is a calcification of the me- dial layer of . ”Typical morphology of such calcifications in the early stages of the disease is linear de- posits along the . arteries in the absence of atherosclerotic plaque. Mayo Clin.

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Hypertension, 55pp. Support Center Support Center. She attained menopause at the age of Treatment Percutaneous angioplasty was performed with drug eluting stents to the monckeberh coronary artery and the left anterior descending artery in a staged approach. Correspondence to Dr G Vivek moc.

Arch Pathol Lab Med,pp. It is frequent to found ulcers of arterial type in the upper and lower limbs of distal predominance, so serious that sometimes may require arteriozclerosis of the extremity to control the symptoms. Although these lesions do not usually invade the vessel walls, the arteries affected may also develop atherosclerosis. Electromyography plus conduction velocities of the 4 extremities was performed, evidencing a chronic axonal sensorimotor polyneuropathy, denervation with increased amplitude of motor unit action potentials and neuropathic recruitment in distal muscles.

Monckeberg’s arteriosclerosis – Wikipedia

Open wrteriosclerosis a separate window. This article has been cited by other articles in PMC. Calcification of Monckeberg’s medial layer is more prevalent in people older than 50 years and in males.

Carotid artery calcifications radiographically appear as curvilinear irregular parallel radiopacities in the soft tissues of the neck at or below the third and fourth cervical vertebrae, and inferior and lateral to the hyoid bone.


Monckeberg’s arteriosclerosis

Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. Arteriosclerosix was the formation of an unusual process of arteriosclerosis, different from the traditional atherosclerosis, which, through an anatomopathological study of the amputation piece, proved to be calcification of Monckeberg’s medial layer. The result is progressive stiffening of the elastic layer of the arterial wall.

After a prolonged stay in the intensive care unit, the patient was transferred to hospitalization, where steroid clearing was started and she died 8 days later due to ventilatory failure, for which no confirmatory clinical necropsy was performed.

Accelerated atherosclerotic calcification and Monckeberg’s sclerosis: Numerous regulators of calcification such as osteopontinosteoprotegerinmatrix gla protein and fetuin-Areceptor activator of NF-kappa-Breceptor activator of NF-kappa-B ligand and tumor necrosis factor TNF -related apoptosis-inducing ligand protein have been implicated in this process.

Soft tissue calcifications in the maxillofacial area are relatively common and can occur as the result of physiologic or pathologic mineralization, and generally correspond to radiographic findings in routine examinations, such as panoramic radiographs. Slices of vessels and smooth muscle cells of the middle layer, focally replaced by hyalinized fibrous tissue presenting concentric dystrophic calcification. It may also result arteriosclegosis “pulselessness.

Mönckeberg medial calcific sclerosis | Radiology Reference Article |

We conclude that Monckeberg’s sclerosis can coexist with coronary artery disease, and can result in unanticipated difficulty in arterial catheterisation. Vascular calcification is a common consequence of aging and is more frequent in patients with diabetes, dyslipidemia, genetic diseases, and diseases involving disturbances of calcium metabolism. Cineangiocoronariography was attempted to directly analyse any coronary disease as a possible cause of these abnormalities, but the rigidity of femoral and brachial arteries impeded the insertion of the catheter.

Treatment of the disease is not well established. Differentiation of multipotent vascular stem cells contributes to vascular diseases.


Am Heart J, 26pp. Am J Physiol Endocrinol Metab. The proper interpretation of radiographic images presupposes a thorough knowledge of the anatomy, distribution, number, size, and shape of the calcifications. A year-old man with a medical history of stage III nasopharyngeal cancer, end-stage renal disease treated with dialysis, hyperthyroidism, type 2 diabetes mellitus, hypertension, atrial fibrillation, and secondary hyperparathyroidism presented at the Oral Medicine Clinic of the College of Dentistry, University of Florida arterioslerosis dental evaluation prior to the start of radiotherapy.

The patient continued hemodynamically unstable, with important ischemia of lower limbs, quite possibly worsened by the use of vasopressors and the hypoperfusion state, so she required finally infracondylar amputation of the left lower limb.

Mönckeberg’s sclerosis – is the artery the only target of calcification?

It can be observed a micrograph of an arterial wall with atherosclerotic calcium plaque violet, hematoxylin—eosin staining. Medial arterial calcification and diabetic neuropathy.

Further studies are needed for a better understanding of this disease, as well as to improve its diagnosis and treatment. Calcifications, arterial stiffness and atherosclerosis.

Arterioscelrosis arteriosclerosis can nonckeberg a rare cause of severe lower limb ischemia. A vaginal hysterectomy with pelvic floor repair was done on December 9, Incidentally detected Monckeberg’s sclerosis in a diabetic with coronary artery disease. However, the present case report raises extensive questions about the etiopathogenic process involved in MS, since this is the first report of soft tissue calcification related to this disease.

Carlos Eduardo Barra Couri: All authors have equally contributed in the preparation and revision of the manuscript.