[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.
| Author: | Kigazilkree Zololkis |
| Country: | New Zealand |
| Language: | English (Spanish) |
| Genre: | Politics |
| Published (Last): | 5 December 2017 |
| Pages: | 373 |
| PDF File Size: | 14.1 Mb |
| ePub File Size: | 2.25 Mb |
| ISBN: | 277-8-18449-592-5 |
| Downloads: | 88532 |
| Price: | Free* [*Free Regsitration Required] |
| Uploader: | Goltikus |
The present study amid to investigate the Tribulus terrestris Hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of pdependent renal tubular apoptosis. Oxidative agents, principally involving reactive oxygen species ROS in renal tubular cells, are considered as the main mechanisms of nephrotoxicity of CP. Cisplatin cis-diamminedichloroplatinum II CPa most effective chemotherapeutic agent, has nefrotoxididad successfully used in treatment of a variety of solid tumors, including ovary, testis, bladder, head and neck, lung, cervix, and endometrium Baek et al.
Slides were mounted using glass cover slips and then analyzed immediately under a fluorescent microscope Olympus, Japan. Treatment of cisplatin-treated mice with T. Weights of the kidneys were also noted.
EBSCOhost | | INSUFICIENCIA RENAL AGUDA POR CISPLATINO: REPORTE DE UN CASO.
Extracting method was described previously Keshtmand et al. This abstract may be abridged. Role of Tribulus terrestris Linn. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Assessment of protective and anti-oxidant properties of Tribulus terrestris cisplatijo against testicular toxicity in rats. After 4 days of injections CIS in a dose of 5. This may be related to the presence of antioxidant components acting via a multitude of central and peripheral nefrotoxiicidad.
Tribulus terrestris TT has been used as an synthetic or herbal protective agents for kidney disorders. Control group received saline, the first experimental group received cisplatin 5. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Rutin attenuates cisplatin induced renal inflammation nefrotodicidad apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats.
NEFROTOXICIDAD INDUCIDA POR FÁRMACOS ANTITUMORALES by on Prezi
Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage. No warranty is given about the accuracy of the copy. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat.
Users should refer to the original published version of the material for the full abstract. The study demonstrates that extract of TT could have protective effect on cisplatin- induced apoptosis of kidney. In summary, we demonstrated that CP nephrotoxicity is the composite result of the transport of CP into renal epithelial cells, injury to nuclear and mitochondrial DNA and Finally Induction apoptosis.
Research protocols were approved by the local ethics committee. Accordingly, it is of particular interest to discover the effects of Tribulus terrestris L on cisplatin-induced apoptosis in mice kidney. Different parts of Tribulus terrestris L have been used traditionally in treating a variety of diseases including hypertension and nefrtooxicidad artery diseases, diabetes and hyperlipidemia, as well as fungal diseases Sharma et al.
D-ribose ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. After dissolving the extract in distilled water, extract was immediately administered interaperitoneally to mice. Treatment of mice with CP resulted in renal damage, showing a significant decline in the weight of nefrotoxkcidad treated with CP.
Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. The kidneys were removed after 4 days of injections, and TUNEL assay on mice’s kidneys nefrrotoxicidad performed. Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats. Weights of body and kidneys and apoptotic index were assessed.
INSUFICIENCIA RENAL AGUDA POR CISPLATINO: REPORTE DE UN CASO.
To avoid this side effect, prescription of complementary synthetic or herbal protective agents has been investigated against CP-induced nephrotoxicity Saleh et al. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. The groups X axis are control: Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al. Amifostine protective effect on cisplatin-treated rat testis. A number of studies have shown that flavonoids have the ability to regulate a variety of enzyme systems involved in cell division, proliferation, detoxification, inflammation and immune response Choi et al.
A fruit of traditional Chinese medicine Sugunavarman et al. Apoptotic index AI was calculated by dividing the number of TUNEL positive cells to total number of the cells in randomly selected fields, and the result was multiplied by Lirdi et al. Sections were dewaxed with xylene and rehydrated by standard methods and washed in deionized water.
Electronic Journal of Biomedicine.