Hepatocellular carcinoma is a tumor with a high incidence and high mortality. These data .. manejo del CHC celebrada en Barcelona en el an˜o definieron por vez primera .. hepática (clasificación Child-Pugh) y presencia de sıntomas. The present manuscript depicts the Barcelona‐Clínic Liver Cancer Group diagnostic and treatment strategy. This is based on the analysis of. The value of the Barcelona Clinic Liver Cancer and alpha-fetoprotein in the Conclusiones: nuestros resultados confirman que la clasificación BCLC es un.
|Published (Last):||21 June 2004|
|PDF File Size:||20.35 Mb|
|ePub File Size:||3.76 Mb|
|Price:||Free* [*Free Regsitration Required]|
Critical appraisal of HCC classifications and future prospects There is no doubt that the classical staging systems have already been improved. Treatment failure was defined as the persistence of contrast enhancement within the tumoral area after completing treatment. Analysis based on serum alpha-fetoprotein levels. This study includes the widest comparison among staging systems, in comparison with other retrospective studies in which the limited collection of data impairs the ability to test all the systems available.
Analysis of hepatocellular carcinoma patients in southern Taiwan: The BCLC staging system may discriminate patients at early stages, and guide the treatment strategy. Proposal of a modified cancer of the liver italian program staging system based hepatocarcinomw the model for end-stage liver disease for patients with hepatocellular carcinoma undergoing loco-regional therapy.
Hospital Virgen de la Salud. The conventional staging systems for hepatocellular carcinoma HCCsuch as the Okuda stage or the TNM stage have shown important limitations in classifying patients.
Staging systems in hepatocellular carcinoma
In this way, in the last years there were improvements in the different prognostic scores. Several reasons explain the difficulty in identifying a world-wide system. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. The strategic role of staging in the treatment of HCC.
Staging systems in hepatocellular carcinoma
An increased incidence in southern Europe is probably related to hepatitis B and C infection and increasing alcohol intake 5which are major risk factors for HCC 2,6.
In fact, the new editions of the staging systems appear to have better prognostic stratification than older ones 27,33,44 and we think AFP can be a factor in the improvement of the BCLC system, although, we cannot say for sure how, due to the low number of patients in our study.
The median survival among each group was: Environmental factors and risk for hepatocellular carcinoma. A total of 6 patients 4. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Patients at stage A with early HCC are candidates for radical therapies resection, liver transplantation or percutaneous treatments.
The mean follow-up period of all patients was Fagiuoli S, et al. We regularly phone the patients when they don’t keep an appointment. The prognostic value of AFP has not been properly defined. The Okuda classification 7 has been widely applied in HCC patients in the last decade.
Thorgeirsson S, Grisham J. HCC is now the leading cause of death among cirrhotic patients 3. Hepatocellular carcinoma in cirrhosis: The decision for therapy was made by the specialist practitioner and in special cases made by a multidisciplinary team consisting of hepatologists, oncologists, radiologists hepatocarcijoma surgeons. Study of patients.
The critical issue of hepatocellular carcinoma prognostic classification: As such, it is necessary to improve the prediction of the prognosis of these patients in order to properly identify the potential candidates for therapy and to critically evaluate the results of new treatment modalities.
In a meta-analysis study of untreated patients the pooled estimated of BCLC B stage 1-year survival rate was Med Clin Barc ; Morbidity and mortality in compensated cirrhosis type C: A total of patients with HCC were analyzed clasificaciom this study.
The aim of this study was to evaluate the BCLC classification in our clinical practice and to know what the prognostic value of AFP is. In the progression of chronic inflammation to fibrosis and cirrhosis, the up-regulation of mitogenic pathways leads to the production of monoclonal populations.
In Western countries and Japan, hepatitis C virus HCV infection is the main risk factor, together with other causes of cirrhosis 46. LlovetSenior Scientist 1 2.
The prognosis of HCC was dismal two decades ago 7. Natural history of compensated viral cirrhosis: Clinical characteristics and prognosis of hepatocellular carcinoma.
The molecular pathogenesis of HCC is complex barfelona Levy I, Sherman M.
Staging systems in HCC Cancer staging should serve to select the appropriate primary and adjuvant therapy, to estimate the prognosis, and also to assist in the evaluation of the results of treatment, and to exchange information without ambiguity Univariate survival curves were estimated using the Kaplan-Meier method; the differences in the survival rates between the groups were compared using the log-rank test.
In brief, patients at stage 0 with very early HCC are optimal candidates for resection. Prognostic prediction and treatment strategy in hepatocellular carcinoma. The potential relevance of a molecular signature identified in terms of outcome prediction should ultimately be tested in large cohorts of patients and analysed together with well-known clinical variables, as has been done recently for breast cancer