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In addition to organotypic cultures, techniques for culturing cell suspensions obtained by enzymatic dissociation have recently been refined. Cau, Pierre Overview. French 30 English 9. The results confirmed the cutaneous passage of the two active ingredients and helped to determine their topical bioavailability.
A histological study and a quantitative microscopy analysis show that the topical application of the statin-aminobisphosphonate combination statistically increases ermal thickness, the increase in both epidermis and cartilage thickness being at the limit of statistical significance. An abnormal protein, progerin, synthesized in a rare genetic disease called Progeria resulting in child accelerated aging, also accumulates pifrre physiological aging, in the absence of mutation, in nucleus of cells, particularly keratinocytes and dermal fibroblasts.
In order to verify the activity of the statin-aminobiphosphonates association on skin aging, a comparative, double-blind, randomized clinical study was then conducted in humans during three months. Biloogie de biologie cellulaire by Pierre Cau Book 9 editions published between and in French and held by WorldCat member libraries worldwide. In a second time, in order to quantify the rate of percutaneous absorption of active ingredients, a diffusion study was performed in vitro on pig ear skin via static Franz diffusion cells.
An oil-in-water emulsion containing two boologie has been developed and applied on the right mouse ear during 28 days; a placebo formula was applied on the left ear. By comparison with a placebo and with a commercially available cosmetic, the cosmetic preparation containing the statin4 aminobisphosphonate combination leads to a statistically significant reduction of fine lines and wrinkles and a decrease in volume of the hollow of the cheek.
Thus, the statin-aminobisphosphonate combination exhibits skin anti-aging properties.
Cau, Pierre 1947-
Cell culture of mutant or wildtype mouse neural crest cells of both genotypes has permitted the comparison and discovery of molecular differences introduced by these mutations. In contrast, NrasG12D mice are viable, present extracutaneous melanocytosis in various sites as well as postnatal hyperpigmentation of the skin. It has been demonstrated that a combination of a statin and an aminobisphosphonate reduces the synthesis of isoprenoid group and reduces as well the cellular toxicity of progerin.
This is associated with increased hair follicle density, and a deregulated hair cycle. Cytology Medicine Morphogenesis Organ culture Thyroid gland.
Cau, Pierre [WorldCat Identities]
The first part of this work is to study in vivo, on mouse ear, the effect of a topical administration of a statin-aminobisphosphonate combination. The development of techniques for culturing bilogie of higher animals, in particular the thyroid by Carrel and Burrows and Champy, allowed the study of the survival in vivo or in vitro of grafts or explants of thyroid gland obtained from adult or fetal animals.
AuthorThesis advisorOpponent The largest CMN, covering entire segments of the body or head, are syndromic. Morphogenesis of thyroid follicles in vitro by Pierre Cau Book 8 editions published in in Plerre and held by WorldCat member libraries worldwide The thyroid gland first appears in the phylogenic scale in the Lamprey larva, Ammocoetes, at the time of metamorphosis see review by Constantinescu, Moreover, histological examination of pathological human glands and adult thyroids experimentally stimulated by thyrotropin hormone TSH has provided additional data for the understanding of thyroid follicle morphogenesis.
Project Page Feedback Known Problems. The toxicity of progerin is related to the persistence of an isoprenoid group, which anchors the progerin to the nucleoplasmic face of the nuclear envelope, and causes abnormalities in the nuclear matrix composition and functions.
BrafVE mutant embryos are embryonic lethal at mid-gestation, probably due to coinciding vascular and brain defects.
We can conclude that both topically administered molecules penetrate the different skin layers. In higher Vertebrates the adult thyroid gland consists of vesicles i.
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Since the end of the 19th century, many authors have studied the morphoge nesis of the follicles during the embryonic and fetal development of the gland in Man and other species, principally Chick, Rat and Rabbit.
The “iterative deconvolution” procedure used in the analysis by the “cross-fire method” of electron microscope autoradiograms ; application to the detection membrane sources by Pierre Cau 1 edition published in in English and held by 1 WorldCat member library worldwide.
For cosmetic applications, the systemic exposure dose SED was used to calculate the margin of safety MS required by cosmetic regulatory rules. De plus, l’expression placentaire de CD et les concentrations de CDs varient au cours de grossesses pathologiques. Abnormal proliferation of melanocyte precursors before birth can lead to human congenital melanocytic nevus CMN.
They arise from a multipotent embryonic cell population called the neural crest, which also gives rise to the peripheral nervous system of the body and many other cell ceellulaire.
Most widely held works by Pierre Cau. Objective physical measurements of skin micro-relief on crows’ feet and of the hollow cheek were performed at time 0 and after 28, 56 and 84 days of cosmetic treatment.