Exanthematous drug eruptions. • «rashes». • Urticaria immediate reactions. • Delayed appearing exanthems with cell infiltration it is frequent. Therapy for exanthematous drug eruptions is supportive, involving the administration of oral antihistamines, topical steroids, and moisturizing. Morbilliform or exanthematous drug reaction (maculopapular drug eruption). Authoritative facts about the skin from DermNet New Zealand.

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Often, however, these patients have been on multiple drugs, which complicate the clinical picture.

The patient should be made aware that pruritus and erythema may be severe. They mainly affect people prescribed beta-lactam antibiotics penicillinscephalosporinssulfonamides, allopurinol, anti-epileptic drugs and nonsteroidal anti- inflammatory drugs NSAID.

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On rechallenge with a drug that the patient has been sensitized to in the past, the eruption may occur within 24 hours. Lower potency topical steroids, such as hydrocortisone 2. Lipodystrophy syndrome, nucleoside reverse transcriptase inhibitors, and protease inhibitors”. There are no routine tests to make the diagnosis or to identify the culprit drug. To identify the possible causative drug, a eruptioh calendar, including all prescribed and over-the counter products, may be helpful.

J Am Acad Dermatol. Patients may develop a peripheral eosinophilia in concert with MDE. An in-depth history and a drug chart may be required to assist in identification of the offending drug.


Morbilliform drug eruption usually first appears on the trunk and then spreads to the limbs and neck. The patient and family should be aware that this is a lifelong reaction and that it will recur with the same drug, or with a drug of the same structural class. Morbilliform drug eruption is the most common form of drug eruption.

Clinical practice. Exanthematous drug eruptions.

In cases where the offending drug is not able to be discontinued, a discussion should be held regarding the risks and benefits of this, both with the dermatologist and the primary subspecialty team concerned. The most important thing is to identify the causative drug and if possible, stop it. A sandpaper-like eruption accompanies a sore throat and fever. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug. Morbilliform drug eruption is a form of allergic reaction.

A multitude of drugs have been implicated in MDE. The term “morbilliform” connotes a measles-like: Exanthem Drug eruptions Allergies explained Other websites: As MDE resolves, it begins to look dusky and violaceous. Expected results of diagnostic studies The diagnosis is made based on the typical clinical appearance in concert with an appropriate drug history and the absence of systemic involvement.

Clinical practice. Exanthematous drug eruptions.

Acute graft-versus host-disease GVHD. Exanthemayous the DermNet NZ bookstore. In cases where it is not possible to do this, such as an antibiotic that is crucial to a drug regimen, symptomatic and supportive treatment while continuing the drug therapy is a feasible option.


Diagnosis confirmation The following conditions should be considered in the differential diagnosis: Antihistamines are also useful when itch is severe. A postinflammatory fine desquamation may also be seen.

The distribution is bilateral and symmetrical. Antiretroviral agents, such as the protease inhibitors, emtricitabine and tenofovir, and tealprevir for hepatitis C infection have also been reported to induce MDE. Confluence and severity is worst in dependent areas, such as the back in hospitalized patients Figure 1.

Morbilliform Drug Eruptions (exanthematous drug eruption; maculopapular drug eruption, “drug rash”)

In typical cases, a biopsy is not required. Toxin-mediated erythemas, such as toxic shock syndrome and Strep toxic shock-like syndrome may present exanthhematous an eruption that resembles MDE.

In the early phase, it may not be possible to clinically eru;tion an uncomplicated morbilliform eruption from other more serious cutaneous adverse reactions SCAR. Here, the rash will get worse before it ultimately gets better and resolves. Further investigations will depend on clinical features, progress of the patient, and the results of the initial tests.