As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.
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Kyron T – View Specifications & Details by Corel Pharma Chem, Ahmedabad | ID:
Required quantity is from 2. A quantity of powder equivalent to 10 mg of metoclopramide hydrochloride was extracted in pH 6. A blend of crospovidone and Kyron T in the ratio of 1: The objective of co-processing is to provide the synergy of functionality improvement as well as to provide an excipient with multiple characteristics build into them [ 6 ]. The cumulative percent drug released from formulation F-X was compared with the tablets obtained from conventional method of manufacture as well as kyeon commercial conventional formulation CCF figs.
The tapped density was determined as the ratio of weight to the volume of sample after tapping a measuring cylinder for times on an Electrolab Tap density tester. Topics Discussed in This Paper.
View Contact Call Seller Now. Zero-order rate equation describes the one whose rate is independent of the concentration of drug undergoing reaction, while the first-order rate equation describes the one whose rate is directly proportional to the concentration of drug undergoing reaction.
The study was also aimed to facilitate rapid disintegration of tablets in oral cavity without need of water t314 subsequent dissolution of active pharmaceutical ingredient to elicit quick onset of action. Gangurde Department of Pharmaceutics, K.
The reasons for selection of crospovidone are high capillary activity, pronounced hydration capacity and little tendency to form gels. Among the tablets evaluated, formulation F-X prepared by adding co-processed superdisintegrants in ratio of 1: Melt-in-mouth tablets each containing 10 mg of metoclopramide hydrochloride were prepared by direct compression method employing crospovidone, Kyron T, physical blend and co-processed mixture of both the superdisintegrants in different ratios 1: For the measurement of angle of repose, a glass funnel was secured with its tip at a given height h above a piece of graph paper placed on a horizontal surface.
Kyron T Get Latest Price. About The Authors B.
Evaluation of KYRON T-314 ( Polacrillin Potassium ) as a novel super disintegrant
Unique porous particle morphology facilitates wicking of liquid into the pores of t-3114 tablet and makes it suitable for direct compression [ 8 ]. The prepared mixture was evaluated for flow properties and polymer-polymer compatibility studies such as FTIR study.
The result of flow property of formulations indicates that the blends were free flowing. Disintegrant Khron Tablet computer Compliance behavior. In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. References Publications referenced by this paper.
This study revealed that -t314 co-processed mixture of superdisintegrants have excellent flow properties, high compressibility, render low disintegration time to tablets and have better binding properties as compared to physical blends of superdisintegrants. Pilot study of relative bioavailability of two oral formulations of ketoprofen 25 mg in healthy subjects.
This is achieved predominantly because of solvent evaporation method. Article Tools Print this article.
Kyron T is high molecular weight polymer, so doesn’t get absorbed by body tissue and is safe for human consumption. Wetting time and water absorption ratio which is an important criteria for understanding the capacity of superdisintegrants to swell in the presence of little amount of water was found to be in the kyyron of Citations Publications citing this paper.
Comparison between wetting time and in vitro dispersion time of all the prepared formulations is shown in fig.
An FTIR kyyron of drug with physical blend and co-processed mixture of superdisintegrants was also recorded. One of the main objectives of the present study was to prepare co-processed superdisintegrants of crospovidone and Kyron T which avoids the problem of segregation of individual superdisintegrants. Rapid disintegrating agent Elimination of t3-14 formation Compatible with all therapeutic agents and excipients Imparts excellent strength to the tablets Elimination of the sticking problems to the dies and punch Improves bioavailability of the drug Uniformly mix with low dose tablets blend or formulations Smooth surface after storage Provide smooth cream-like mouth feel, so more suitable for ODT Suitable for both direct compression and wet granulation methods Cost effective White in color Directly compressible grade Dissolution improver Effective at very low concentration 0.
In vitro dissolution studies on all the prepared metoclopramide hydrochloride melt-in-mouth tablets were performed in pH 6. The reasons for selection of Kyron T are very high swelling tendency of hydration either in contact with water or gastrointestinal fluids causing very fast disintegration without the lump formation.
Besides, our company is t-134 enough to provide effective solutions to various industry’s specific problems and kyroh. Kyron T has a very high swelling tendency of hydration either in contact with water or G. Showing of 2 extracted citations. College of Pharmacy, Chandwad Nasik India. Orodispersible tablets ODTsalso known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water.
Cumulative percent drug released was calculated and kinetic study models like zero-order and first-order were applied [ 15 ]. A piece of tissue paper folded kkyron was placed in a small petridish i. Formulation design and optimization h-314 mouth dissolve tablets of nimesulide using vacuum drying technique Mukesh GohelMadhabhai M.
The flow prpoperties were shown in Table 3. The punches and die were lubricated with a small amount of magnesium stearate using a cotton swab preceding compression. From This Paper Figures, tables, and topics from this paper. The bulk density was determined as the ratio of weight to the volume of sample. Related Items Author’s work. Table 4 and 5 depicts all the tablet parameters evaluated.
Formulation of certain active pharmaceutical ingredients can not be achieved adequately with the use of single component excipient [ 4 ]. Fast-melting tablets based on highly plastic granules. Aceclofenac in the management of inflammatory pain. Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion Omaima A.