As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.
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Gangurde Department of Pharmaceutics, K. Aceclofenac in the management of inflammatory pain. Required quantity is from 0. These materials can be a good substitute for inert superdisintegrants, which are normally used in tablet manufacturing.
Direct compression, co-processed superdisintegrants, solvent-evaporation, crospovidone, Kyron T, metoclopramide hydrochloride, wetting time. All the tablet formulations were evaluated for flow property and compression characteristics. View Contact Call Seller Now. Formulation F-X was emerged as the overall best formulation based on drug release characteristics in pH 6.
The t-3114 formulation F-X was compared g-314 commercial conventional marketed tablets for percentage metoclopramide hydrochloride dissolved. Skip to search form Skip to main content. Co-processed superdisintegrants were prepared by incorporating one superdisintegrants into the particle structure of another using solvent evaporation method. Then the ingredients were weighed and mixed in geometrical order and compressed into tablets of mg using 6 mm round flat punches on a Rimek mini press 1 Karnavati.
Kyron T – View Specifications & Details by Corel Pharma Chem, Ahmedabad | ID:
Presently, our organization has become lyron of the prominent engineering group who has all the modern facilities for designing, developing and manufacturing defect free range of Polymers oyron the clients. About The Authors B.
As seen from Table 4 and 5all the tablets subjected to uniformity of drug content revealed the tablets to contain metoclopramide hydrochloride equivalent to metoclopramide between Email this article Login required. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.
The coprocessed superdisintegrants were prepared by solvent evaporation method. Product Description As Disintegrating agent: Toxicity Kyron T is high molecular weight polymer, so doesn’t get absorbed by body tissue and t314 safe for human consumption.
The flow properties were graded as per the USP specifications [ 15 ]. Required quantity is from 2. It is available in white free flowing powder hence it is suitable for the both wet granulation as well as direct compression system for tablet formulations. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
Unique porous particle morphology facilitates wicking of liquid into the pores of the tablet and makes it suitable for direct compression [ 8 ]. Jadon Editorial Members Prof. The cumulative percent t-3314 released from formulation F-X was compared with the tablets obtained from conventional method of manufacture as well as with commercial conventional formulation Kyrin figs. Formulation and optimization of t314 dissolve tablets containing rofecoxib solid dispersion Omaima A.
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In comparison to direct compression tablets containing the physical blends of crospovidone and Kyron T, a faster drug release was observed from the tablets made from coprocessed superdisintegrants which might be attributed to increased porosity. In vitro dissolution studies on all the prepared metoclopramide hydrochloride melt-in-mouth tablets t-3144 performed in pH 6.
Citations Publications citing this paper. Abstract Orodispersible tablets ODTsalso known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water.
In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. WaghSapna S. Among the tablets evaluated, formulation F-X prepared by adding co-processed superdisintegrants in ratio of 1: Related Items Author’s work. Topics Discussed in This Paper.
Evaluation of KYRON T-314 ( Polacrillin Potassium ) as a novel super disintegrant
Table 1 shows the parameters associated with flow of physical blend and co-processed mixture of crospovidone and Kyron T The result of flow property of formulations indicates that the blends were free flowing. A total of thirteen formulations were designed and evaluated including control formulation without superdisintegrants and also compared with the marketed preparation Table 2.
FTIR spectrum of physical and co-processed mixture of polymer and their comparisons with drug. Rapid disintegrating agent Elimination of lump formation Compatible with all therapeutic agents and excipients Imparts excellent strength to the tablets Elimination of the sticking problems to the dies and punch Improves bioavailability of the drug Uniformly mix with low dose tablets t-34 or formulations Smooth surface after storage ,yron smooth cream-like mouth feel, so more suitable for ODT Suitable for both direct compression and wet granulation methods Cost effective White in kygon Directly compressible grade Dissolution improver Effective at very low concentration 0.
Undoubtedly, all the formulations showed very short disintegration time, apart from fulfilling all compendial and other standard specifications, and exhibited faster release rates of metoclopramide hydrochloride. Since mechanical integrity is of paramount importance in successful formulation of melt-in-mouth tablets, the hardness of the tablets was found to be in t-341 range of 3.
The contents of lyron beaker ml capacity were stirred on a magnetic stirrer. The authors are also grateful to Gujarat Microwax Pvt. The simple physical blends and co-processed mixture of superdisintegrants were characterized for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and compatibility studies by FTIR spectroscopy.
Kyron T is high molecular weight polymer, so khron get absorbed by body tissue and h-314 safe for human consumption. Spray dried excipient base: In order to describe the kinetics of the release process of drug in all the prepared formulations, zero-order and first-order rate equations were used. The study was also aimed to facilitate rapid disintegration of tablets in oral cavity without need of water and subsequent dissolution of active pharmaceutical ingredient to elicit quick onset of action.
BairagiValmik R Patil